SnapShot: T Cell Exhaustion
نویسندگان
چکیده
منابع مشابه
Blimp-1 Expression as an Exhaustion Transcription Factor in Chronic Lymphocytic Leukemia
Background: PPreviously, it was shown that exhausted CD4+ and CD8+ T cells in chronic lymphocytic leukemia (CLL) co-express the two immune-inhibitory receptors, Tim-3 and PD-1. Present study investigated the expression of Blimp-1, a transcription factor involved in T cell exhaustion, in patients with CLL. Materials and Methods: Peripheral blood mononuclear cells were collected from 25 untreate...
متن کاملReversal of T-cell exhaustion as a strategy to improve immune control of HIV-1.
T-cell exhaustion is a state of functional immune impairment characterized by reduced T-cell proliferation, cytokine production, cytotoxic function, and cell survival [1]. Although exhaustion generally contributes positively to immune tolerance, it also impairs tumor-specific and virus-specific T cells to allow evasion of immune surveillance [1]. Many cell surface inhibitory receptors have been...
متن کاملChronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion.
The failure of CD8(+) T cells to respond to chronic infection has been termed "exhaustion" and describes the condition in which CD8(+) T cells exhibit reduced differentiation, proliferation, and effector function. CD8(+) T cell exhaustion has been extensively studied in the murine model of chronic infection, lymphocytic choriomeningitis virus (LCMV). Although LCMV-based studies have yielded man...
متن کاملGenetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells
Programmed Death-1 (PD-1) has received considerable attention as a key regulator of CD8(+) T cell exhaustion during chronic infection and cancer because blockade of this pathway partially reverses T cell dysfunction. Although the PD-1 pathway is critical in regulating established "exhausted" CD8(+) T cells (TEX cells), it is unclear whether PD-1 directly causes T cell exhaustion. We show that P...
متن کاملRole of Tim3 in Mediating T Cell Exhaustion During Chronic Mycobacterium Tuberculosis Infection
Mycobacterium tuberculosis infection is one of the leading causes of mortality worldwide. One third of the population is estimated to be infected, however only 5-10% of those individuals can transmit the disease. While T cell immunity initially limits mycobacterium growth, it is unclear why T cell immunity fails to sterilize the infection and prevent subsequent recrudescence. One hypothesis is ...
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عنوان ژورنال:
- Cell
دوره 163 شماره
صفحات -
تاریخ انتشار 2015